Creatinine Clearance Calculator

Creatinine clearance (CrCl) measures how quickly the kidneys remove creatinine from the blood and is calculated from serum creatinine, age, weight, and sex. Glomerular filtration rate (GFR) is a direct measure of kidney filtration capacity, usually reported as eGFR (estimated GFR) using the CKD-EPI or MDRD equations. Both are proxies for kidney function. Cockcroft-Gault CrCl is preferred for drug dosing because most drug package inserts were developed using that formula. CKD-EPI eGFR is preferred for CKD staging and epidemiology.

Creatinine is produced by muscle metabolism. On average, women have less skeletal muscle mass than men of the same height and weight, so they produce less creatinine per day. The 0.85 correction factor (a 15% reduction) approximates this average difference. Note that this is a group average - highly muscular women or women with very low muscle mass (e.g., sarcopenia) will have results that diverge from the population norm.

This calculator expects mg/dL. Convert umol/L to mg/dL by dividing by 88.42. For example, 100 umol/L ÷ 88.42 ≈ 1.13 mg/dL. Make sure the conversion is correct before entering the value.

No. This tool provides an estimate for educational purposes only. Medication dosing based on kidney function is a clinical decision that requires: the correct body weight type (actual vs. ideal vs. adjusted), current clinical context, other labs, and professional pharmaceutical expertise. Always consult your pharmacist and prescribing physician for dosing guidance. This calculator is for informational purposes only and does not constitute medical advice.